An imbalance in the surface tension in a liquid, due either to a concentration or thermal gradient, causes a flow that is known as Marangoni effect. During last decade, being motivated by the need to carry out batch or semi-batch fluidic operations on a surface, various attempts have been made to utilize Marangoni effect for inducing motion of liquid drops on a solid surface. A simple method that received considerable success uses a gradient of surface wettability that can be prepared by diffusion controlled silanization of a silicon wafer or a glass slide. Nevertheless, a significant detriment to the progress of this technology arises from the wetting hysteresis. Recent studies show that the hysteresis can be reduced or eliminated by supplying a periodic inertial force to the drop that allows it to sample various metastable states, thereby setting it to the path of global energy minima. Significant amplification of velocity is observed with the frequency of forcing vibration matching the natural spherical harmonics of drop oscillation. Further studies show that the main cause for velocity amplification is related to resonant shape fluctuation, which can be utilized in the design of miniaturized fluidic and thermal management systems.